RRC ID 41504
著者 Washburn NR, Simon CG Jr, Tona A, Elgendy HM, Karim A, Amis EJ.
タイトル Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology.
ジャーナル J Biomed Mater Res
Abstract A methodology for the preparation of porous scaffolds for tissue engineering using co-extrusion is presented. Poly(epsilon-caprolactone) is blended with poly(ethylene oxide) in a twinscrew extruder to form a two-phase material with micron-sized domains. Selective dissolution of the poly(ethylene oxide) with water results in a porous material. A range of blend volume fractions results in co-continuous networks of polymer and void spaces. Annealing studies demonstrate that the characteristic pore size may be increased to larger than 100 microm. The mechanical properties of the scaffolds are characterized by a compressive modulus on the order of 1 MPa at low strains but displaying a marked strain-dependence. The results of osteoblast seeding suggest it is possible to use co-extrusion to prepare polymer scaffolds without the introduction of toxic contaminants. Polymer co-extrusion is amenable to both laboratory- and industrial-scale production of scaffolds for tissue engineering and only requires rheological characterization of the blend components. This method leads to scaffolds that have continuous void space and controlled characteristic length scales without the use of potentially toxic organic solvents.
巻・号 60(1)
ページ 20-9
公開日 2002-4-1
DOI 10.1002/jbm.10049
PII 10.1002/jbm.10049
PMID 11835155
MeSH Algorithms Biocompatible Materials* Bone Screws Cells, Cultured Materials Testing Microscopy, Electron, Scanning Microscopy, Fluorescence Osteoblasts Polyesters Polyethylene Glycols Polymers* Rheology Stress, Mechanical Surface Properties Temperature Viscosity
引用数 84
WOS 分野 ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS
リソース情報
ヒト・動物細胞 MC3T3-E1(RCB1126)