RRC ID |
41504
|
著者 |
Washburn NR, Simon CG Jr, Tona A, Elgendy HM, Karim A, Amis EJ.
|
タイトル |
Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology.
|
ジャーナル |
J Biomed Mater Res
|
Abstract |
A methodology for the preparation of porous scaffolds for tissue engineering using co-extrusion is presented. Poly(epsilon-caprolactone) is blended with poly(ethylene oxide) in a twinscrew extruder to form a two-phase material with micron-sized domains. Selective dissolution of the poly(ethylene oxide) with water results in a porous material. A range of blend volume fractions results in co-continuous networks of polymer and void spaces. Annealing studies demonstrate that the characteristic pore size may be increased to larger than 100 microm. The mechanical properties of the scaffolds are characterized by a compressive modulus on the order of 1 MPa at low strains but displaying a marked strain-dependence. The results of osteoblast seeding suggest it is possible to use co-extrusion to prepare polymer scaffolds without the introduction of toxic contaminants. Polymer co-extrusion is amenable to both laboratory- and industrial-scale production of scaffolds for tissue engineering and only requires rheological characterization of the blend components. This method leads to scaffolds that have continuous void space and controlled characteristic length scales without the use of potentially toxic organic solvents.
|
巻・号 |
60(1)
|
ページ |
20-9
|
公開日 |
2002-4-1
|
DOI |
10.1002/jbm.10049
|
PII |
10.1002/jbm.10049
|
PMID |
11835155
|
MeSH |
Algorithms
Biocompatible Materials*
Bone Screws
Cells, Cultured
Materials Testing
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Osteoblasts
Polyesters
Polyethylene Glycols
Polymers*
Rheology
Stress, Mechanical
Surface Properties
Temperature
Viscosity
|
引用数 |
84
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
リソース情報 |
ヒト・動物細胞 |
MC3T3-E1(RCB1126) |