論文 - 詳細
| RRC ID | 41580 |
|---|---|
| 著者 | Fujita M, Hayashi I, Yamashina S, Itoman M, Majima M. |
| タイトル | Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
It was reported that angiotensin II stimulates angiogenesis in vivo, and angiotensin-converting enzyme (ACE) inhibitors inhibit angiogenesis. We found that an AT1-receptor (AT1-R) antagonist, TCV-116, inhibited tumor growth, tumor-associated angiogenesis, and metastasis in a murine model. Tumor growth of Sarcoma 180 (S-180) cells and of fibrosarcoma (NFSA) cells was strongly inhibited by administration of TCV-116 in the diet at a dose of approximately 100 mg/kg/day. This reduction was accompanied with a marked reduction in tumor-associated angiogenesis. The same treatment also reduced the lung metastasis of intravenously injected Lewis lung carcinoma cells. These effects of TCV-116 were equivalent to those of the ACE inhibitor, lisinopril. In S-180 and NFSA tumor tissues, ACE and AT1a receptor (AT1a-R) mRNAs were expressed when assessed with RT-PCR. AT1b receptor and AT2 receptor, however, were not detected. Immunoreactive AT1-R was detected mainly on the neovascularized vascular endothelial cells in which expression was reduced by TCV-116 and lisinopril. These results suggested that TCV-116 inhibits the angiogenesis, growth, and metastasis of tumors highly dependent on AT1a-R blockade. Blockade of AT1a-R signaling may therefore become an effective novel strategy for tumor chemoprevention. |
| 巻・号 | 294(2) |
| ページ | 441-7 |
| 公開日 | 2002-6-7 |
| DOI | 10.1016/S0006-291X(02)00496-5 |
| PII | S0006-291X(02)00496-5 |
| PMID | 12051731 |
| MeSH | Angiotensin Receptor Antagonists* Animals Antihypertensive Agents / pharmacology Antineoplastic Agents / pharmacology Benzimidazoles / pharmacology* Biphenyl Compounds / pharmacology* Carcinoma, Lewis Lung / drug therapy* Carcinoma, Lewis Lung / metabolism Carcinoma, Lewis Lung / pathology Cell Division / drug effects Drug Screening Assays, Antitumor Fibrosarcoma / drug therapy* Fibrosarcoma / metabolism Fibrosarcoma / pathology Immunohistochemistry Lisinopril / pharmacology Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred ICR Neoplasm Metastasis / prevention & control Neoplasm Transplantation Neovascularization, Pathologic / prevention & control Peptidyl-Dipeptidase A / biosynthesis Peptidyl-Dipeptidase A / genetics RNA, Messenger / biosynthesis Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin / biosynthesis Receptors, Angiotensin / genetics Sarcoma 180 / drug therapy Sarcoma 180 / metabolism Sarcoma 180 / pathology Sarcoma, Experimental / drug therapy* Sarcoma, Experimental / metabolism Sarcoma, Experimental / pathology Signal Transduction / drug effects* Tetrazoles* |
| IF | 2.985 |
| 引用数 | 180 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 115 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| ヒト・動物細胞 | NFSa Y83(RCB0282) |