論文 - 詳細
RRC ID | 41624 |
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著者 | Nonaka M, Ikeda H, Inokuchi T. |
タイトル | Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro. |
ジャーナル | Cancer Lett |
Abstract |
We investigated the cytotoxic and apoptotic effects of a combination of photodynamic therapy (PDT) and cisplatin (CDDP) on L5178Y (LY) cells. Treatment with PDT by photofrin((R)) (5 microg/ml) alone or with CDDP (20 microg/ml) alone killed 41.5+/-8.5% or 42.9+/-6.5% of LY cells, respectively, while a combination of these two treatments killed 99.7+/-0.6%. Apoptotic cell death after combination treatment was also revealed to be 49.6+/-7.8% compared to 12.4+/-3.4% after PDT alone, and 18.8+/-2.6% after CDDP. This study demonstrated that combined treatment of PDT and CDDP results in enhanced apoptotic cell death as well as a cytotoxic effect on LY cells. |
巻・号 | 184(2) |
ページ | 171-8 |
公開日 | 2002-10-28 |
DOI | 10.1016/s0304-3835(02)00208-2 |
PII | S0304383502002082 |
PMID | 12127689 |
MeSH | Antineoplastic Agents / toxicity* Apoptosis / drug effects* Cell Survival / drug effects* Cisplatin / toxicity* Dihematoporphyrin Ether / toxicity* Humans Photochemotherapy* Tumor Cells, Cultured |
IF | 7.36 |
引用数 | 30 |
WOS 分野 | ONCOLOGY |
リソース情報 | |
ヒト・動物細胞 | L5178Y(RCB0135) |