RRC ID 41624
著者 Nonaka M, Ikeda H, Inokuchi T.
タイトル Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro.
ジャーナル Cancer Lett
Abstract We investigated the cytotoxic and apoptotic effects of a combination of photodynamic therapy (PDT) and cisplatin (CDDP) on L5178Y (LY) cells. Treatment with PDT by photofrin((R)) (5 microg/ml) alone or with CDDP (20 microg/ml) alone killed 41.5+/-8.5% or 42.9+/-6.5% of LY cells, respectively, while a combination of these two treatments killed 99.7+/-0.6%. Apoptotic cell death after combination treatment was also revealed to be 49.6+/-7.8% compared to 12.4+/-3.4% after PDT alone, and 18.8+/-2.6% after CDDP. This study demonstrated that combined treatment of PDT and CDDP results in enhanced apoptotic cell death as well as a cytotoxic effect on LY cells.
巻・号 184(2)
ページ 171-8
公開日 2002-10-28
DOI 10.1016/s0304-3835(02)00208-2
PII S0304383502002082
PMID 12127689
MeSH Antineoplastic Agents / toxicity* Apoptosis / drug effects* Cell Survival / drug effects* Cisplatin / toxicity* Dihematoporphyrin Ether / toxicity* Humans Photochemotherapy* Tumor Cells, Cultured
IF 7.36
引用数 30
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 L5178Y(RCB0135)