論文 - 詳細
| RRC ID | 41632 |
|---|---|
| 著者 | Onoue S, Endo K, Yajima T, Kashimoto K. |
| タイトル | Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide attenuate glutamate-induced nNOS activation and cytotoxicity. |
| ジャーナル | Regul Pept |
| Abstract |
Both vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) act as neurotransmitters in the central and peripheral nervous systems. Attention has been focused on these neuropeptides because among their numerous biological activities, they have been confirmed to show neuroprotective effects against ischemia and glutamate-induced cytotoxicity. It is well established that glutamate has excitatory effects on neuronal cells, and that excessive glutamate shows potent neurotoxicity, especially in neuronal nitric oxide synthase-containing neurons. Glutamate stimulates the production of nitric oxide (NO) in neurons, and the NO generated is tightly associated with the delayed death of neurons. We examined the effects of these neuropeptides on the glutamate-induced neural actions using PC12 cells, and we confirmed the important activities of PACAP/VIP on the production of NO as well as the delayed cell death stimulated by glutamate. |
| 巻・号 | 107(1-3) |
| ページ | 43-7 |
| 公開日 | 2002-7-15 |
| DOI | 10.1016/s0167-0115(02)00065-4 |
| PII | S0167011502000654 |
| PMID | 12137965 |
| MeSH | Animals Cell Survival Dose-Response Relationship, Drug Drug Interactions Enzyme Activation / drug effects Enzyme Inhibitors / pharmacology Glutamic Acid / toxicity Neuropeptides / chemical synthesis Neuropeptides / genetics Neuropeptides / pharmacology* Nitric Oxide / biosynthesis* Nitric Oxide Synthase / antagonists & inhibitors* Nitric Oxide Synthase / metabolism Nitric Oxide Synthase Type I Nitrites / analysis PC12 Cells Pituitary Adenylate Cyclase-Activating Polypeptide RNA, Messenger / biosynthesis Rats Receptors, Vasoactive Intestinal Peptide / biosynthesis Receptors, Vasoactive Intestinal Peptide / genetics Vasoactive Intestinal Peptide / chemical synthesis Vasoactive Intestinal Peptide / pharmacology* |
| 引用数 | 26 |
| WOS 分野 | PHYSIOLOGY ENDOCRINOLOGY & METABOLISM |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |