論文 - 詳細
| RRC ID | 41707 |
|---|---|
| 著者 | Morita H, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J. |
| タイトル | Cytokine production by the murine macrophage cell line J774.1 after exposure to lactobacilli. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 to secrete cytokines. Some of the bacteria tested induce the production of interleukin(IL) 6, IL-12, and tumor necrosis factor a (TNF-alpha) by J774.1 cells. Seven strains also induced the production of IL-10. However, no IL-1beta was produced. Lactobacillus acidophilus TMC 0356 significantly induced the production of more IL-6, IL-10, IL-12, and TNF-alpha than the other bacteria tested (p < 0.0001; ANOVA). These results suggest that lactobacilli can activate macrophages to secrete both inflammatory and anti-inflammatory cytokines. Selected strains might be used to bring about pro or antiinflammatory immune reactions. |
| 巻・号 | 66(9) |
| ページ | 1963-6 |
| 公開日 | 2002-9-1 |
| DOI | 10.1271/bbb.66.1963 |
| PMID | 12400700 |
| MeSH | Animals Cell Line Cytokines / biosynthesis* Lactobacillus / physiology* Macrophage Activation Macrophages / immunology Macrophages / metabolism* Macrophages / microbiology* Mice |
| IF | 1.516 |
| 引用数 | 88 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |