論文 - 詳細
| RRC ID | 41800 |
|---|---|
| 著者 | Wu J, Xia HH, Tu SP, Fan DM, Lin MC, Kung HF, Lam SK, Wong BC. |
| タイトル | 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. |
| ジャーナル | Carcinogenesis |
| Abstract |
It has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells. We found that a specific cyclooxygenase-2 (COX-2) inhibitor SC-236 similarly induced apoptosis in gastric cancer cells. In the present study, we tested whether SC-236 induced apoptosis through up-regulation of 15-LOX-1 in gastric cancer. We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis. These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer. |
| 巻・号 | 24(2) |
| ページ | 243-7 |
| 公開日 | 2003-2-1 |
| DOI | 10.1093/carcin/24.2.243 |
| PMID | 12584173 |
| MeSH | Apoptosis / drug effects* Arachidonate 15-Lipoxygenase / genetics Arachidonate 15-Lipoxygenase / metabolism* Base Sequence Caffeic Acids / pharmacology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors / pharmacology* DNA Primers Isoenzymes / drug effects* Linoleic Acids / pharmacology Prostaglandin-Endoperoxide Synthases / drug effects* Pyrazoles / pharmacology* RNA, Messenger / genetics Reverse Transcriptase Polymerase Chain Reaction Stomach Neoplasms / enzymology Stomach Neoplasms / pathology* Sulfonamides / pharmacology* Tumor Cells, Cultured |
| IF | 4.603 |
| 引用数 | 55 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MKN45(RCB1001) MKN28(RCB1000) |