RRC ID 41829
Author Sato K, Yamashita N, Yamashita N, Baba M, Matsuyama T.
Title Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse.
Journal Immunity
Abstract We have established a novel immunotherapeutic approach involving dendritic cells (DCs) with potent immunoregulatory property (designated as regulatory DCs [rDCs]) for acute graft-versus-host disease (GVHD) and leukemia relapse in allogeneic bone marrow (BM) transplantation (BMT) in mice bearing leukemia. rDCs displayed high levels of MHC molecules and extremely low levels of costimulatory molecules. A single injection of rDCs following allogeneic BMT controlled the ability of the transplanted T cells to induce acute GVHD and graft-versus-leukemia (GVL) effect in the recipients bearing leukemia, and that resulted in protection from the lethality caused by acute GVHD and tumor burden. Thus, the use of rDCs may be therapeutically useful for the treatment of acute GVHD and leukemia relapse in allogeneic BMT.
Volume 18(3)
Pages 367-79
Published 2003-3
DOI 10.1016/s1074-7613(03)00055-4
PII S1074-7613(03)00055-4
PMID 12648454
MeSH Acute Disease Animals Bone Marrow Transplantation CD4-Positive T-Lymphocytes / immunology CD4-Positive T-Lymphocytes / metabolism CD8-Positive T-Lymphocytes / immunology Cell Cycle Proteins / metabolism Cyclic AMP / metabolism Cyclin-Dependent Kinase Inhibitor p27 Dendritic Cells / immunology* Female Graft vs Host Disease / immunology Graft vs Host Disease / prevention & control* Graft vs Leukemia Effect Immunotherapy In Vitro Techniques Leukemia, Experimental / immunology Leukemia, Experimental / therapy* Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA Transplantation, Homologous Tumor Suppressor Proteins / metabolism
IF 21.522
Times Cited 255
Human and Animal Cells