| RRC ID |
41829
|
| 著者 |
Sato K, Yamashita N, Yamashita N, Baba M, Matsuyama T.
|
| タイトル |
Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse.
|
| ジャーナル |
Immunity
|
| Abstract |
We have established a novel immunotherapeutic approach involving dendritic cells (DCs) with potent immunoregulatory property (designated as regulatory DCs [rDCs]) for acute graft-versus-host disease (GVHD) and leukemia relapse in allogeneic bone marrow (BM) transplantation (BMT) in mice bearing leukemia. rDCs displayed high levels of MHC molecules and extremely low levels of costimulatory molecules. A single injection of rDCs following allogeneic BMT controlled the ability of the transplanted T cells to induce acute GVHD and graft-versus-leukemia (GVL) effect in the recipients bearing leukemia, and that resulted in protection from the lethality caused by acute GVHD and tumor burden. Thus, the use of rDCs may be therapeutically useful for the treatment of acute GVHD and leukemia relapse in allogeneic BMT.
|
| 巻・号 |
18(3)
|
| ページ |
367-79
|
| 公開日 |
2003-3-1
|
| DOI |
10.1016/s1074-7613(03)00055-4
|
| PII |
S1074-7613(03)00055-4
|
| PMID |
12648454
|
| MeSH |
Acute Disease
Animals
Bone Marrow Transplantation
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / metabolism
CD8-Positive T-Lymphocytes / immunology
Cell Cycle Proteins / metabolism
Cyclic AMP / metabolism
Cyclin-Dependent Kinase Inhibitor p27
Dendritic Cells / immunology*
Female
Graft vs Host Disease / immunology
Graft vs Host Disease / prevention & control*
Graft vs Leukemia Effect
Immunotherapy
In Vitro Techniques
Leukemia, Experimental / immunology
Leukemia, Experimental / therapy*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Transplantation, Homologous
Tumor Suppressor Proteins / metabolism
|
| IF |
22.553
|
| 引用数 |
255
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
