Reference - Detail
|Author||Awale S, Tezuka Y, Banskota AH, Kadota S.|
|Title||Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship.|
|Journal||Biol Pharm Bull|
Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.
|MeSH||Animals Cell Line Cell Survival / drug effects Cell Survival / physiology Diterpenes / chemistry Diterpenes / isolation & purification Diterpenes / pharmacology* Dose-Response Relationship, Drug Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / antagonists & inhibitors* Nitric Oxide / biosynthesis* Orthosiphon* Oxygen / chemistry Oxygen / isolation & purification Oxygen / pharmacology* Structure-Activity Relationship|
|WOS Category||PHARMACOLOGY & PHARMACY|
|Human and Animal Cells|