RRC ID 41839
Author Awale S, Tezuka Y, Banskota AH, Kadota S.
Title Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship.
Journal Biol Pharm Bull
Abstract Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.
Volume 26(4)
Pages 468-73
Published 2003-4
DOI 10.1248/bpb.26.468
PMID 12673027
MeSH Animals Cell Line Cell Survival / drug effects Cell Survival / physiology Diterpenes / chemistry Diterpenes / isolation & purification Diterpenes / pharmacology* Dose-Response Relationship, Drug Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / antagonists & inhibitors* Nitric Oxide / biosynthesis* Orthosiphon* Oxygen / chemistry Oxygen / isolation & purification Oxygen / pharmacology* Structure-Activity Relationship
IF 1.54
Times Cited 23
Human and Animal Cells