Reference - Detail
Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for cholinergic function. These include two enzymes, two transporters, and a bewildering assortment of receptors. Cholinergic transmission is involved, directly or indirectly, in many C. elegans behaviors, including locomotion, egg laying, feeding, and male mating.
|MeSH||Acetylcholine / biosynthesis Acetylcholine / physiology* Acetylcholinesterase / metabolism Animals Biological Transport Caenorhabditis elegans / drug effects Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Choline / metabolism Cytoplasmic Vesicles / physiology Humans Receptors, Cholinergic / genetics Receptors, Cholinergic / metabolism|