| RRC ID |
41870
|
| Author |
Shiba T, Nishimura D, Kawazoe Y, Onodera Y, Tsutsumi K, Nakamura R, Ohshiro M.
|
| Title |
Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate.
|
| Journal |
J Biol Chem
|
| Abstract |
The proliferation of normal human fibroblast cells was enhanced by the addition of inorganic polyphosphate (poly(P)) into culture media. The mitogenic activities of acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) were also enhanced by poly(P). A physical interaction between poly(P) and FGF-2 was observed, and FGF-2 was both physically and functionally stabilized by poly(P). Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs.
|
| Volume |
278(29)
|
| Pages |
26788-92
|
| Published |
2003-7-18
|
| DOI |
10.1074/jbc.M303468200
|
| PII |
S0021-9258(20)84636-5
|
| PMID |
12740373
|
| MeSH |
3T3 Cells
Animals
Cell Division / drug effects
Cells, Cultured
Culture Media
Fibroblast Growth Factor 1 / metabolism
Fibroblast Growth Factor 1 / pharmacology
Fibroblast Growth Factor 2 / metabolism
Fibroblast Growth Factor 2 / pharmacology
Fibroblast Growth Factors / metabolism
Fibroblast Growth Factors / pharmacology*
Fibroblasts / cytology
Fibroblasts / drug effects
Fibroblasts / metabolism
Humans
Kinetics
Mice
Mitogens / metabolism
Mitogens / pharmacology*
Polyphosphates / metabolism
Polyphosphates / pharmacology*
Protein Binding
Receptor Protein-Tyrosine Kinases / metabolism
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor / metabolism
|
| IF |
4.238
|
| Times Cited |
98
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
