論文 - 詳細
| RRC ID | 41878 |
|---|---|
| 著者 | Okuyama-Tamura M, Mikuni M, Kojima I. |
| タイトル | Modulation of the human glucocorticoid receptor function by antidepressive compounds. |
| ジャーナル | Neurosci Lett |
| Abstract |
Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained translocation of GR into the nucleus of human lymphocytes. In contrast, major and minor tranquilizers, lithium and verapamil, a blocker of membrane steroid transporter, were without effect. These antidepressants did not affect GR-mediated transcription by themselves, but significantly inhibited dexamethasone-induced transcription. These results indicate that structurally different antidepressants induce translocation of GR and inhibit GR-mediated transcription. |
| 巻・号 | 342(3) |
| ページ | 206-10 |
| 公開日 | 2003-5-22 |
| DOI | 10.1016/s0304-3940(03)00261-1 |
| PII | S0304394003002611 |
| PMID | 12757900 |
| MeSH | Animals Antidepressive Agents / classification Antidepressive Agents / pharmacology* Blood Cells / drug effects Blood Cells / metabolism COS Cells / drug effects COS Cells / metabolism Dexamethasone / pharmacology Drug Interactions Gene Expression Regulation / drug effects Glucocorticoids / pharmacology Humans Immunohistochemistry / methods Lithium / pharmacology Receptors, Glucocorticoid / blood Receptors, Glucocorticoid / drug effects Receptors, Glucocorticoid / metabolism* Tranquilizing Agents / pharmacology Transcription, Genetic / drug effects* Transfection / methods Translocation, Genetic / drug effects |
| IF | 2.274 |
| 引用数 | 38 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| ヒト・動物細胞 | COS |