| RRC ID |
41879
|
| 著者 |
Matsuo K, Oka M, Murase K, Soda H, Isomoto H, Takeshima F, Mizuta Y, Murata I, Kohno S.
|
| タイトル |
Expression of interleukin 6 and its receptor in human gastric and colorectal cancers.
|
| ジャーナル |
J Int Med Res
|
| Abstract |
Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions. The present study was designed to determine the expression of IL-6 and its receptor (IL-6R) in human gastric and colorectal cancers. Nine gastric- and nine colorectal cancer cell lines were analysed. The IL-6 gene was expressed in two gastric cancer cell lines and one colorectal cancer cell line; however, most of the cancer cell lines studied expressed the IL-6R gene. The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< approximately 100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines (< approximately 50 pg/ml). These results suggest that IL-6 may act in a paracrine fashion rather than an autocrine fashion in these cell lines.
|
| 巻・号 |
31(2)
|
| ページ |
69-75
|
| 公開日 |
2003-1-1
|
| DOI |
10.1177/147323000303100202
|
| PMID |
12760309
|
| MeSH |
Cell Line, Tumor
Colorectal Neoplasms / genetics
Colorectal Neoplasms / metabolism*
Gene Expression Regulation, Neoplastic*
Humans
Interleukin-6 / metabolism*
Stomach Neoplasms / genetics
Stomach Neoplasms / metabolism*
|
| IF |
1.287
|
| 引用数 |
33
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
|
