Reference - Detail
| RRC ID | 41899 |
|---|---|
| Author | Uda A, Tanabayashi K, Mukai R, Terao K, Yamada A. |
| Title | Identification of an amino acid responsible for the CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis). |
| Journal | J Med Primatol |
| Abstract |
The FN18 monoclonal antibody (mAb), directed to CD3 molecules, did not react with the lymphocytes of some cynomolgus monkeys (Macaca fascicularis), because of the polymorphism of the CD3epsilon chain. The epitope recognized by the FN18 mAb was successfully expressed on COS7 cells upon transfection of plasmid DNA coding for the CD3epsilon derived from T cells of a FN18 positive cynomolgus monkey. By construction and expression of plasmid DNA encoding the mutant CD3epsilon, the amino acid residue at position 67 was demonstrated to be involved in the formation of an epitope recognizable by the FN18 mAb. |
| Volume | 32(2) |
| Pages | 105-10 |
| Published | 2003-4-1 |
| DOI | 10.1034/j.1600-0684.2003.00012.x |
| PII | 012 |
| PMID | 12823633 |
| MeSH | Amino Acid Sequence Animals Antibodies, Monoclonal / immunology* Antibody Specificity Base Sequence CD3 Complex / chemistry CD3 Complex / genetics* CD3 Complex / immunology* COS Cells Epitopes / genetics* Epitopes / immunology* Macaca fascicularis / genetics* Macaca fascicularis / immunology Molecular Sequence Data Mutation Polymorphism, Genetic* |
| IF | 0.553 |
| Times Cited | 4 |
| WOS Category | VETERINARY SCIENCES ZOOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 16 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | COS-7(RCB0539) |