RRC ID 41949
Author Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.
Title Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
Journal J. Nat. Prod.
Abstract We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
Volume 66(8)
Pages 1124-7
Published 2003-8
DOI 10.1021/np020546u
PMID 12932141
MeSH Apoptosis / drug effects* Blotting, Western Garcinia / chemistry* HL-60 Cells / drug effects Humans Indonesia Inhibitory Concentration 50 Leukemia Molecular Structure Plants, Medicinal / chemistry* Stereoisomerism Tumor Cells, Cultured / drug effects Xanthones / chemistry Xanthones / isolation & purification* Xanthones / pharmacology
IF 3.885
Times Cited 109
WOS Category CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES
Resource
Human and Animal Cells