| RRC ID |
41949
|
| 著者 |
Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.
|
| タイトル |
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
|
| 巻・号 |
66(8)
|
| ページ |
1124-7
|
| 公開日 |
2003-8-1
|
| DOI |
10.1021/np020546u
|
| PMID |
12932141
|
| MeSH |
Apoptosis / drug effects*
Blotting, Western
Garcinia / chemistry*
HL-60 Cells / drug effects
Humans
Indonesia
Inhibitory Concentration 50
Leukemia
Molecular Structure
Plants, Medicinal / chemistry*
Stereoisomerism
Tumor Cells, Cultured / drug effects
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology
|
| IF |
3.782
|
| 引用数 |
144
|
|
WOS 分野
|
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
|
| リソース情報 |
| ヒト・動物細胞 |
K562(RCB0027)
HL60(RCB0041)
U-937 DE-4(RCB0435) |
