RRC ID 41955
Author Yoshida K.
Title Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7a and 7b isoforms of protocadherin 7, but not the 7c isoform.
Journal Cell Mol Biol Lett
Abstract Protocadherins (Pcdhs) are a family of cadherins considered to play an important role in the cell-cell adhesion of specific neurons in the central nervous system. Of the reported Pcdhs, relatively little is known about the functional role of protocadherin 7 (Pcdh7), and there is no evidence of Pcdh7 mediated cell-cell adhesion. To date, three splicing variants are known; they may have different effects on cell phenotype. We report here that mouse fibroblast L cells stably overexpressing the Pcdh7 isoforms 7a and 7b, but not 7c, showed a morphological change and Ca(2+)dependent cell adhesion.
Volume 8(3)
Pages 735-41
Published 2003-1-1
PMID 12949613
MeSH Animals Blotting, Western Cadherins / genetics Cadherins / metabolism* Cell Adhesion Cell Size Fibroblasts / cytology Fibroblasts / metabolism* Immunohistochemistry L Cells Mice Protein Isoforms / genetics Protein Isoforms / metabolism
IF 3.451
Times Cited 30
Human and Animal Cells