論文 - 詳細
| RRC ID | 42008 |
|---|---|
| 著者 | Murakami M, Ikeda T, Ogawa K, Funaba M. |
| タイトル | Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We explored transcriptional regulation of mouse mast cell protease-9 (mMCP-9), which is implicated in inflammation of the jejunum during helminth infections and tissue remodeling of the uterus during pregnancy. Transcription was positively regulated by microphthalmia-associated transcription factor (MITF), a member of the basic helix-loop-helix-leucine zipper family that binds to the E-box, a CANNTG sequence. The most significant segment for positive regulation by MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which bound MITF-M. In addition, not only other MITF isoforms but also TFE3, another member of the family, activated mMCP-9 transcription through this nucleotide sequence inserted one base within the E-box. |
| 巻・号 | 311(1) |
| ページ | 4-10 |
| 公開日 | 2003-11-7 |
| DOI | 10.1016/j.bbrc.2003.09.148 |
| PII | S0006291X03019661 |
| PMID | 14575687 |
| MeSH | Amino Acid Motifs Animals DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Female Gene Expression Regulation, Enzymologic / physiology* Humans Male Mast Cells / chemistry Mast Cells / enzymology* Melanoma, Experimental / chemistry Melanoma, Experimental / enzymology* Melanoma, Experimental / genetics Mice Microphthalmia-Associated Transcription Factor Protein Binding Serine Endopeptidases / chemistry Serine Endopeptidases / genetics Serine Endopeptidases / metabolism* Transcription Factors / chemistry Transcription Factors / genetics Transcription Factors / metabolism* Transcriptional Activation / genetics Transcriptional Activation / physiology* Up-Regulation / physiology |
| IF | 2.985 |
| 引用数 | 13 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |