RRC ID 42111
著者 Tsukushi Y, Kido N, Saeki K, Sugiyama T, Koide N, Mori I, Yoshida T, Yokochi T.
タイトル Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium.
ジャーナル J Endotoxin Res
Abstract The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-alpha and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.
巻・号 10(1)
ページ 25-31
公開日 2004-1-1
DOI 10.1179/096805104225003799
PMID 15025821
MeSH Animals Biological Assay Escherichia coli / pathogenicity Horseshoe Crabs Lipopolysaccharides / isolation & purification* Lipopolysaccharides / pharmacology* Nitric Oxide / analysis Proteobacteria / pathogenicity* Sinorhizobium / pathogenicity* Structure-Activity Relationship Tumor Necrosis Factor-alpha / biosynthesis
引用数 8
WOS 分野 MEDICINE, RESEARCH & EXPERIMENTAL IMMUNOLOGY MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 RAW 264(RCB0535)