| RRC ID |
42111
|
| 著者 |
Tsukushi Y, Kido N, Saeki K, Sugiyama T, Koide N, Mori I, Yoshida T, Yokochi T.
|
| タイトル |
Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium.
|
| ジャーナル |
J Endotoxin Res
|
| Abstract |
The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-alpha and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.
|
| 巻・号 |
10(1)
|
| ページ |
25-31
|
| 公開日 |
2004-1-1
|
| DOI |
10.1179/096805104225003799
|
| PMID |
15025821
|
| MeSH |
Animals
Biological Assay
Escherichia coli / pathogenicity
Horseshoe Crabs
Lipopolysaccharides / isolation & purification*
Lipopolysaccharides / pharmacology*
Nitric Oxide / analysis
Proteobacteria / pathogenicity*
Sinorhizobium / pathogenicity*
Structure-Activity Relationship
Tumor Necrosis Factor-alpha / biosynthesis
|
| 引用数 |
8
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
IMMUNOLOGY
MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
