| RRC ID |
42135
|
| Author |
Caillet-Fauquet P, Di Giambattista M, Draps ML, Sandras F, Branckaert T, de Launoit Y, Laub R.
|
| Title |
Continuous-flow UVC irradiation: a new, effective, protein activity-preserving system for inactivating bacteria and viruses, including erythrovirus B19.
|
| Journal |
J Virol Methods
|
| Abstract |
Despite the increasing number of screening tests being introduced, ensuring the inactivation of blood-borne pathogens in blood-derived therapeutic material is a major concern. Dynamic continuous-flow UVC irradiation is a new way to inactivate a large range of pathogens without adding any photosentizers. The efficacy of different methods was evaluated against the following viruses: murine parvovirus MVMp, human B19, the encephalomyocarditis virus (EMC, a picornavirus used as a model for model for hepatitis A virus), and bovine herpes virus type 1 (BHV, a model for enveloped viruses such as hepatitis B virus). We show that continuous-flow UVC irradiation is very effective, particularly against resistant pathogens (e.g. parvoviruses and bacteria) at UVC doses preserving protein activity. It may be applicable to newly emerging related viruses or variants.
|
| Volume |
118(2)
|
| Pages |
131-9
|
| Published |
2004-6-15
|
| DOI |
10.1016/j.jviromet.2004.02.002
|
| PII |
S0166093404000400
|
| PMID |
15081608
|
| MeSH |
Animals
Bacteria / radiation effects*
Blood Proteins / metabolism
Blood Proteins / radiation effects
Blood-Borne Pathogens / radiation effects*
Cattle
Disinfection / methods*
Factor VIII / metabolism
Fibrinogen / metabolism
Humans
Immunoglobulins / metabolism
Mice
Parvovirus B19, Human / radiation effects
Plasma / radiation effects
Ultraviolet Rays*
Viruses / radiation effects*
|
| IF |
1.786
|
| Times Cited |
39
|
|
WOS Category
|
BIOCHEMICAL RESEARCH METHODS
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
VIROLOGY
|
| Resource |
| Human and Animal Cells |
KU812F(RCB0497) |
