Reference - Detail
RRC ID | 42143 |
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Author | Nguyen MT, Awale S, Tezuka Y, Chien-Hsiung C, Kadota S. |
Title | Staminane- and isopimarane-type diterpenes from Orthosiphon stamineus of Taiwan and their nitric oxide inhibitory activity. |
Journal | J Nat Prod |
Abstract |
From the MeOH extract of Taiwanese Orthosiphon stamineus, two new staminane-type diterpenes, staminols C (1) and D (2), and three new isopimarane-type diterpenes, orthosiphonone C (3) and D (4) and 14-deoxo-14-O-acetylorthosiphol Y (5), have been isolated together with 16 known diterpenes, orthosiphols A, B, D, K, M, N, O, X, and Y, nororthosiphonolide A, neoorthosiphol B, orthosiphonone A, secoorthosiphols B and C, 3-O-deacetylorthosiphol I, and 2-O-deacetylorthosiphol J. Their structures were determined on the basis of the spectroscopic data. All the newly isolated diterpenes exhibited dose-dependent inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells, and 2-O-deacetylorthosiphonone A showed the most potent activity, with an IC(50) value of 35.0 microM, comparable to that of the positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 35.7 microM). |
Volume | 67(4) |
Pages | 654-8 |
Published | 2004-4-1 |
DOI | 10.1021/np030471+ |
PMID | 15104497 |
MeSH | Abietanes / chemistry Abietanes / isolation & purification* Abietanes / pharmacology Cells, Cultured Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology Inhibitory Concentration 50 Macrophages / drug effects Molecular Structure Nitric Oxide / antagonists & inhibitors* Orthosiphon / chemistry* Plants, Medicinal / chemistry* Taiwan omega-N-Methylarginine / pharmacology |
IF | 3.782 |
Times Cited | 23 |
WOS Category | PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
Resource | |
Human and Animal Cells | J774.1(RCB0434) |