論文 - 詳細
| RRC ID | 42150 |
|---|---|
| 著者 | Nakamori M, Fu X, Rousseau R, Chen SY, Zhang X. |
| タイトル | Destruction of nonimmunogenic mammary tumor cells by a fusogenic oncolytic herpes simplex virus induces potent antitumor immunity. |
| ジャーナル | Mol Ther |
| Abstract |
In principle, destruction of tumor cells in vivo by oncolytic agents would release the entire repertoire of tumor antigens in their natural forms, leading to effective antitumor immunity. This goal has been elusive despite extensive testing of numerous strategies. We developed a doubly fusogenic oncolytic herpes simplex virus (Synco-2D) that kills tumor cells by a unique dual mechanism combining direct cytolysis with syncytial formation induced by cell membrane fusion. A single intratumor injection of Synco-2D induced strong antitumor immunity against an otherwise nonimmunogenic murine mammary tumor growing in immune-competent mice. CD8+ T cells were the primary mediators of immunity, contributing to the destruction of both primary and metastatic tumors. We conclude that the fusogenic capacity of Synco-2D enables it to elicit antitumor immunity exceeding that induced by more conventional oncolytic viruses. |
| 巻・号 | 9(5) |
| ページ | 658-65 |
| 公開日 | 2004-5-1 |
| DOI | 10.1016/j.ymthe.2004.02.019 |
| PII | S1525-0016(04)00085-1 |
| PMID | 15120326 |
| MeSH | Animals Carcinoma / immunology Carcinoma / virology Cell Line Cell Survival Female Interferon-gamma / immunology Interleukin-10 / immunology Lung Neoplasms / pathology Lung Neoplasms / secondary Lymphocyte Depletion Mammary Neoplasms, Experimental / immunology* Mammary Neoplasms, Experimental / virology Membrane Fusion Mice Mice, Inbred BALB C Neoplasm Metastasis / pathology Neoplasm Transplantation Simplexvirus / physiology* T-Lymphocytes, Cytotoxic / immunology Tumor Escape / immunology |
| IF | 8.986 |
| 引用数 | 47 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL BIOTECHNOLOGY & APPLIED MICROBIOLOGY GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Meth-A(RCB0464) |