| RRC ID |
42168
|
| Author |
Sakai T, Sameshima T, Matsufuji M, Kawamura N, Dobashi K, Mizui Y.
|
| Title |
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
Seven new macrolides having a 12-membered ring, which we termed pladienolides, were isolated from the fermentation broth of Streptomyces platensis Mer-11107. Six of the seven pladienolides inhibited hypoxia-induced reporter gene expression controlled by human VEGF promoter with IC50 values of 0.0018-2.89 microM. They also demonstrated growth-inhibitory activity against U251 human glioma cells in vitro. Pladienolides are highly potent inhibitors of both hypoxia signals and cancer cell proliferation, and thus may be useful as antitumor agents.
|
| Volume |
57(3)
|
| Pages |
173-9
|
| Published |
2004-3-1
|
| DOI |
10.7164/antibiotics.57.173
|
| PMID |
15152802
|
| MeSH |
Alkaline Phosphatase / drug effects
Alkaline Phosphatase / genetics
Antineoplastic Agents / classification
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Fermentation*
Humans
Isoenzymes / drug effects
Isoenzymes / genetics
Macrolides / classification
Macrolides / isolation & purification*
Macrolides / pharmacology
Streptomyces
Tumor Cells, Cultured / drug effects
Vascular Endothelial Growth Factor A / drug effects
|
| IF |
2.668
|
| Times Cited |
71
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MICROBIOLOGY
IMMUNOLOGY
|
| Resource |
| Human and Animal Cells |
U251(RCB0461) |
