Reference - Detail
| RRC ID | 42168 |
|---|---|
| Author | Sakai T, Sameshima T, Matsufuji M, Kawamura N, Dobashi K, Mizui Y. |
| Title | Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Seven new macrolides having a 12-membered ring, which we termed pladienolides, were isolated from the fermentation broth of Streptomyces platensis Mer-11107. Six of the seven pladienolides inhibited hypoxia-induced reporter gene expression controlled by human VEGF promoter with IC50 values of 0.0018-2.89 microM. They also demonstrated growth-inhibitory activity against U251 human glioma cells in vitro. Pladienolides are highly potent inhibitors of both hypoxia signals and cancer cell proliferation, and thus may be useful as antitumor agents. |
| Volume | 57(3) |
| Pages | 173-9 |
| Published | 2004-3-1 |
| DOI | 10.7164/antibiotics.57.173 |
| PMID | 15152802 |
| MeSH | Alkaline Phosphatase / drug effects Alkaline Phosphatase / genetics Antineoplastic Agents / classification Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Fermentation* Humans Isoenzymes / drug effects Isoenzymes / genetics Macrolides / classification Macrolides / isolation & purification* Macrolides / pharmacology Streptomyces Tumor Cells, Cultured / drug effects Vascular Endothelial Growth Factor A / drug effects |
| IF | 2.668 |
| Times Cited | 71 |
| WOS Category | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | U251(RCB0461) |