Reference - Detail
| RRC ID | 42203 |
|---|---|
| Author | Lee S, Jung SH, Lee YS, Yamada M, Kim BK, Ohuchi K, Shin KH. |
| Title | Antiinflammatory activity of hyperin from Acanthopanax chiisanensis roots. |
| Journal | Arch Pharm Res |
| Abstract |
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E2 (PGE2) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) production in vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 microM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo. |
| Volume | 27(6) |
| Pages | 628-32 |
| Published | 2004-6-1 |
| DOI | 10.1007/BF02980162 |
| PMID | 15283465 |
| MeSH | Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry Anti-Inflammatory Agents, Non-Steroidal / isolation & purification Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Blotting, Western Capillary Permeability / drug effects Cell Survival / drug effects Cells, Cultured Eleutherococcus / chemistry* Injections, Intraperitoneal Macrophages, Peritoneal / cytology Macrophages, Peritoneal / drug effects* Macrophages, Peritoneal / metabolism Male Mice Nitric Oxide Synthase / metabolism Nitrites / metabolism Plant Extracts / chemistry Plant Extracts / pharmacology Plant Roots / chemistry Quercetin / analogs & derivatives* Quercetin / chemistry Quercetin / isolation & purification Quercetin / pharmacology* Rats Rats, Sprague-Dawley |
| IF | 2.934 |
| Times Cited | 27 |
| WOS Category | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |