| RRC ID |
42203
|
| Author |
Lee S, Jung SH, Lee YS, Yamada M, Kim BK, Ohuchi K, Shin KH.
|
| Title |
Antiinflammatory activity of hyperin from Acanthopanax chiisanensis roots.
|
| Journal |
Arch Pharm Res
|
| Abstract |
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E2 (PGE2) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) production in vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 microM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo.
|
| Volume |
27(6)
|
| Pages |
628-32
|
| Published |
2004-6-1
|
| DOI |
10.1007/BF02980162
|
| PMID |
15283465
|
| MeSH |
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Blotting, Western
Capillary Permeability / drug effects
Cell Survival / drug effects
Cells, Cultured
Eleutherococcus / chemistry*
Injections, Intraperitoneal
Macrophages, Peritoneal / cytology
Macrophages, Peritoneal / drug effects*
Macrophages, Peritoneal / metabolism
Male
Mice
Nitric Oxide Synthase / metabolism
Nitrites / metabolism
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Roots / chemistry
Quercetin / analogs & derivatives*
Quercetin / chemistry
Quercetin / isolation & purification
Quercetin / pharmacology*
Rats
Rats, Sprague-Dawley
|
| IF |
2.934
|
| Times Cited |
27
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
