RRC ID 42208
Author Aoki S, Kong D, Matsui K, Rachmat R, Kobayashi M.
Title Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells.
Journal Chem. Pharm. Bull.
Abstract A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.
Volume 52(8)
Pages 935-7
Published 2004-8
DOI 10.1248/cpb.52.935
PII JST.JSTAGE/cpb/52.935
PMID 15304984
MeSH Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Cell Differentiation / drug effects* Erythroblasts / chemistry Erythroblasts / cytology Erythroblasts / drug effects* Hemoglobins / metabolism Humans K562 Cells Porifera / chemistry* Quinones / chemistry Quinones / isolation & purification* Quinones / pharmacology Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification* Sesquiterpenes / pharmacology Structure-Activity Relationship Tumor Cells, Cultured
IF 1.258
Times Cited 31
WOS Category PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL CHEMISTRY, MULTIDISCIPLINARY
Resource
Human and Animal Cells