論文 - 詳細
RRC ID | 42225 |
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著者 | Oyanagi H, Takenaka K, Ishikawa S, Kawano Y, Adachi Y, Ueda K, Wada H, Tanaka F. |
タイトル | Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer. |
ジャーナル | Lung Cancer |
Abstract |
LUN is a novel RING finger protein that is highly expressed in the lung and might be a transcriptional regulator of E-cadherin [J. Biol. Chem. 276 (2001) 14004]. It might be possible that LUN plays important roles in the development and progression of lung cancer through regulating expression of E-cadherin, but no clinical study on LUN expression has been reported. In the present study, we quantitatively examined gene expression of the LUN in surgical specimens resected from non-small cell lung cancer (NSCLC) patients. In normal lung tissues, the LUN gene expression was down-regulated in smokers (the mean LUN/GAPDH ratios, 0.222 for non-smokers and 0.144 for smokers; P = 0.030). In addition, the mean LUN/GAPDH ratio in lung cancer tissues was significantly lower than that in normal lung tissues (0.072 versus 0.162; P < 0.001). In addition, the LUN gene expression was slightly down-regulated along with progression of primary tumors, and strongly down-regulated along with nodal metastases (the mean LUN/GAPDH ratios, 0.091 for pN0, 0.073 for pN1, and 0.034 for pN2 diseases; P = 0.001). These results suggested that LUN might play important roles in inhibition of nodal metastases as well as in suppression of smoking-related oncogenesis in NSCLC. |
巻・号 | 46(1) |
ページ | 21-8 |
公開日 | 2004-10-1 |
DOI | 10.1016/j.lungcan.2004.03.009 |
PII | S0169500204001333 |
PMID | 15364129 |
MeSH | Aged Cadherins / biosynthesis Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / physiopathology* Carrier Proteins / biosynthesis* Carrier Proteins / genetics* Cell Transformation, Neoplastic DNA Topoisomerases, Type I DNA-Binding Proteins / biosynthesis* DNA-Binding Proteins / genetics* Disease Progression Down-Regulation Female Gene Expression Profiling* Humans Lung Neoplasms / genetics* Lung Neoplasms / physiopathology* Lymphatic Metastasis Male Neoplasm Proteins / biosynthesis* Neoplasm Proteins / genetics* Nuclear Proteins / biosynthesis* Nuclear Proteins / genetics* Smoking / adverse effects Transcription Factors / biosynthesis* Transcription Factors / genetics* Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases Zinc Fingers |
IF | 4.702 |
引用数 | 17 |
WOS 分野 | RESPIRATORY SYSTEM ONCOLOGY |
リソース情報 | |
ヒト・動物細胞 | Lu-139(RCB0469) PC-14(RCB0446) A549(RCB0098) HuH-7(RCB1366) Hep G2 COLO-320(RCB1193) MKN1(RCB1003) |