RRC ID 42225
著者 Oyanagi H, Takenaka K, Ishikawa S, Kawano Y, Adachi Y, Ueda K, Wada H, Tanaka F.
タイトル Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer.
ジャーナル Lung Cancer
Abstract LUN is a novel RING finger protein that is highly expressed in the lung and might be a transcriptional regulator of E-cadherin [J. Biol. Chem. 276 (2001) 14004]. It might be possible that LUN plays important roles in the development and progression of lung cancer through regulating expression of E-cadherin, but no clinical study on LUN expression has been reported. In the present study, we quantitatively examined gene expression of the LUN in surgical specimens resected from non-small cell lung cancer (NSCLC) patients. In normal lung tissues, the LUN gene expression was down-regulated in smokers (the mean LUN/GAPDH ratios, 0.222 for non-smokers and 0.144 for smokers; P = 0.030). In addition, the mean LUN/GAPDH ratio in lung cancer tissues was significantly lower than that in normal lung tissues (0.072 versus 0.162; P < 0.001). In addition, the LUN gene expression was slightly down-regulated along with progression of primary tumors, and strongly down-regulated along with nodal metastases (the mean LUN/GAPDH ratios, 0.091 for pN0, 0.073 for pN1, and 0.034 for pN2 diseases; P = 0.001). These results suggested that LUN might play important roles in inhibition of nodal metastases as well as in suppression of smoking-related oncogenesis in NSCLC.
巻・号 46(1)
ページ 21-8
公開日 2004-10-1
DOI 10.1016/j.lungcan.2004.03.009
PII S0169500204001333
PMID 15364129
MeSH Aged Cadherins / biosynthesis Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / physiopathology* Carrier Proteins / biosynthesis* Carrier Proteins / genetics* Cell Transformation, Neoplastic DNA Topoisomerases, Type I DNA-Binding Proteins / biosynthesis* DNA-Binding Proteins / genetics* Disease Progression Down-Regulation Female Gene Expression Profiling* Humans Lung Neoplasms / genetics* Lung Neoplasms / physiopathology* Lymphatic Metastasis Male Neoplasm Proteins / biosynthesis* Neoplasm Proteins / genetics* Nuclear Proteins / biosynthesis* Nuclear Proteins / genetics* Smoking / adverse effects Transcription Factors / biosynthesis* Transcription Factors / genetics* Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases Zinc Fingers
IF 4.702
引用数 17
WOS 分野 RESPIRATORY SYSTEM ONCOLOGY
リソース情報
ヒト・動物細胞 Lu-139(RCB0469) PC-14(RCB0446) A549(RCB0098) HuH-7(RCB1366) Hep G2 COLO-320(RCB1193) MKN1(RCB1003)