論文 - 詳細
| RRC ID | 42250 |
|---|---|
| 著者 | Ikebe T, Nakayama H, Shinohara M, Shirasuna K. |
| タイトル | NF-kappaB involvement in tumor-stroma interaction of squamous cell carcinoma. |
| ジャーナル | Oral Oncol |
| Abstract |
We investigated the interaction between tumor cells and stromal fibroblasts in tumor invasion of oral squamous cell carcinoma. Gelatin zymography showed that high levels of matrix metalloproteinase (MMP)-9 were present in the tissue of squamous cell carcinoma. When tumor cells and fibroblasts were isolated from the tissue and cultured separately, significant levels of MMP-9 were lost in the culture media of tumor cells as well as fibroblasts. When tumor cells and fibroblasts were cocultured in the presence of tumor necrosis factor alpha, high levels of MMP-9 were recovered in the culture media. The levels of MMP-9, which were secreted from tumor cells, but not fibroblasts, correlated with the number of cocultured fibroblasts. Cocultured fibroblasts, moreover, enhanced the induction of an active form of MMP-9, cell motility, and the activation of a transcription factor NF-kappaB in tumor cells. Stromal fibroblasts may induce NF-kappaB activation and promote the invasion of oral squamous cell carcinoma. |
| 巻・号 | 40(10) |
| ページ | 1048-56 |
| 公開日 | 2004-11-1 |
| DOI | 10.1016/j.oraloncology.2004.05.007 |
| PII | S1368-8375(04)00134-4 |
| PMID | 15509497 |
| MeSH | Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology* Cell Communication Cell Movement Coculture Techniques Collagenases / metabolism Enzyme Precursors / metabolism Fibroblasts / pathology Humans Matrix Metalloproteinase 9 / metabolism Mouth Neoplasms / metabolism Mouth Neoplasms / pathology* NF-kappa B / physiology* Neoplasm Invasiveness Stromal Cells / pathology* Tumor Cells, Cultured |
| IF | 3.979 |
| 引用数 | 12 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |