| RRC ID |
42264
|
| Author |
Shida D, Kitayama J, Yamaguchi H, Yamashita H, Mori K, Watanabe T, Yatomi Y, Nagawa H.
|
| Title |
Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.
|
| Journal |
FEBS Lett
|
| Abstract |
Receptor tyrosine kinases (RTKs) are transactivated by the stimulation of G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P), a ligand of GPCR, is known as a tumor-promoting lipid, but its signaling pathways are not fully understood. We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. The pathway of S1P-induced c-Met transactivation is Gi-independent and matrix metalloproteinase-independent, which differs from that of EGFR transactivation. Our results indicate that S1P acts upstream of various RTKs and thus may act as a potent stimulator of gastric cancer.
|
| Volume |
577(3)
|
| Pages |
333-8
|
| Published |
2004-11-19
|
| DOI |
10.1016/j.febslet.2004.10.024
|
| PII |
S001457930401258X
|
| PMID |
15556605
|
| MeSH |
Blotting, Western
Cell Line, Tumor
ErbB Receptors / metabolism*
Humans
Lysophospholipids / genetics
Lysophospholipids / metabolism*
Models, Biological
Phosphorylation
Precipitin Tests
Proto-Oncogene Proteins c-met / metabolism*
Sphingosine / analogs & derivatives*
Sphingosine / genetics
Sphingosine / metabolism*
Stomach Neoplasms / metabolism*
Transcriptional Activation*
Tyrosine / metabolism
|
| IF |
3.057
|
| Times Cited |
49
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
MKN28(RCB1000)
MKN74(RCB1002) |
