Reference - Detail
| RRC ID | 42264 |
|---|---|
| Author | Shida D, Kitayama J, Yamaguchi H, Yamashita H, Mori K, Watanabe T, Yatomi Y, Nagawa H. |
| Title | Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. |
| Journal | FEBS Lett |
| Abstract |
Receptor tyrosine kinases (RTKs) are transactivated by the stimulation of G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P), a ligand of GPCR, is known as a tumor-promoting lipid, but its signaling pathways are not fully understood. We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. The pathway of S1P-induced c-Met transactivation is Gi-independent and matrix metalloproteinase-independent, which differs from that of EGFR transactivation. Our results indicate that S1P acts upstream of various RTKs and thus may act as a potent stimulator of gastric cancer. |
| Volume | 577(3) |
| Pages | 333-8 |
| Published | 2004-11-19 |
| DOI | 10.1016/j.febslet.2004.10.024 |
| PII | S001457930401258X |
| PMID | 15556605 |
| MeSH | Blotting, Western Cell Line, Tumor ErbB Receptors / metabolism* Humans Lysophospholipids / genetics Lysophospholipids / metabolism* Models, Biological Phosphorylation Precipitin Tests Proto-Oncogene Proteins c-met / metabolism* Sphingosine / analogs & derivatives* Sphingosine / genetics Sphingosine / metabolism* Stomach Neoplasms / metabolism* Transcriptional Activation* Tyrosine / metabolism |
| IF | 3.057 |
| Times Cited | 49 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MKN28(RCB1000) MKN74(RCB1002) |