論文 - 詳細
| RRC ID | 42291 |
|---|---|
| 著者 | Feng Y, Matsuura N, Ubukata M. |
| タイトル | Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively. |
| 巻・号 | 57(10) |
| ページ | 627-33 |
| 公開日 | 2004-10-1 |
| DOI | 10.7164/antibiotics.57.627 |
| PMID | 15638322 |
| MeSH | Animals Carbazoles / chemistry Carbazoles / isolation & purification* Carbazoles / pharmacology Cell Differentiation / drug effects Glycine / analogs & derivatives* Indoles / chemistry Indoles / isolation & purification* Indoles / pharmacology Nerve Growth Factor / antagonists & inhibitors* Neurites / drug effects Neurites / physiology Rats Streptomyces / metabolism* Structure-Activity Relationship |
| IF | 2.668 |
| 引用数 | 10 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY PHARMACOLOGY & PHARMACY IMMUNOLOGY MICROBIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |