論文 - 詳細
| RRC ID | 42311 |
|---|---|
| 著者 | Zhang K, Washburn NR, Simon CG Jr. |
| タイトル | Cytotoxicity of three-dimensionally ordered macroporous sol-gel bioactive glass (3DOM-BG). |
| ジャーナル | Biomaterials |
| Abstract |
In this study, 80% SiO(2)-20% CaO (mole fraction) three-dimensionally ordered macroporous sol-gel bioactive glass (3DOM-BG, average pore size: 345 nm) particles were prepared and characterized. Since the 3DOM-BGs have a novel microstructure and ion-releasing profile, the cytotoxicity of 3DOM-BG particles was tested. The cytotoxicity tests were performed using MC3T3-E1 osteoblast-like cells: (1) Wst-1 assay for cell viability after culture in extracts from 3DOM-BG particles; (2) phase contrast microscopy for cell morphology after culture with 3DOM-BG particles; and (3) fluorescence microscopy for imaging cells cultured directly on 3DOM-BG particles. The results showed that 3DOM-BG particles were not cytotoxic, and that cells attached, spread and proliferated on and around 3DOM-BG particles. |
| 巻・号 | 26(22) |
| ページ | 4532-9 |
| 公開日 | 2005-8-1 |
| DOI | 10.1016/j.biomaterials.2004.11.030 |
| PII | S0142-9612(04)01012-9 |
| PMID | 15722122 |
| MeSH | 3T3 Cells Animals Biocompatible Materials* Cell Survival* Glass* Mice Microscopy, Fluorescence |
| IF | 10.317 |
| 引用数 | 28 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |