| RRC ID |
42315
|
| Author |
Ohguchi K, Akao Y, Matsumoto K, Tanaka T, Ito T, Iinuma M, Nozawa Y.
|
| Title |
Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Recently, we found that vaticanol C (a resveratrol tetramer), which was isolated from stem bark of Dipterocarpaceae, exhibited growth suppression and induction of apoptosis via the loss of mitochondrial membrane potential and consequent caspases activation. The detailed mechanisms are not clearly understood. We decided to attempt to gain further insight into the mechanisms underlying vaticanol C-induced apoptosis in HL-60 cells. Treatment of HL-60 cells with vaticanol C was found to cause a marked decrease in the level of phosphorylated extracellular signal-regulated kinase (ERK) concurrent with inhibited phosphorylation of its upstream kinase mitogen-activates protein kinase kinase (MEK). Moreover, exposure to vaticanol C led to a significant reduction in the level of phosphorylated Akt. Thus, vaticanol C induced inhibition of both ERK and Akt phosphorylation, resulting in reduced phosphorylation of Bad. These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways.
|
| Volume |
69(2)
|
| Pages |
353-6
|
| Published |
2005-2-1
|
| DOI |
10.1271/bbb.69.353
|
| PII |
JST.JSTAGE/bbb/69.353
|
| PMID |
15725661
|
| MeSH |
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Enzyme Inhibitors
HL-60 Cells
Humans
MAP Kinase Signaling System / drug effects
Stilbenes / pharmacology*
|
| IF |
1.516
|
| Times Cited |
20
|
|
WOS Category
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
HL60(RCB0041) |
