RRC ID 4236
著者 Gu M, Schuske K, Watanabe S, Liu Q, Baum P, Garriga G, Jorgensen EM.
タイトル Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans.
ジャーナル J Cell Biol
Abstract Synaptic vesicles must be recycled to sustain neurotransmission, in large part via clathrin-mediated endocytosis. Clathrin is recruited to endocytic sites on the plasma membrane by the AP2 adaptor complex. The medium subunit (micro2) of AP2 binds to cargo proteins and phosphatidylinositol-4 ,5-bisphosphate on the cell surface. Here, we characterize the apm-2 gene (also called dpy-23), which encodes the only micro2 subunit in the nematode Caenorhabditis elegans. APM-2 is highly expressed in the nervous system and is localized to synapses; yet specific loss of APM-2 in neurons does not affect locomotion. In apm-2 mutants, clathrin is mislocalized at synapses, and synaptic vesicle numbers and evoked responses are reduced to 60 and 65%, respectively. Collectively, these data suggest AP2 micro2 facilitates but is not essential for synaptic vesicle recycling.
巻・号 183(5)
ページ 881-92
公開日 2008-12-1
DOI 10.1083/jcb.200806088
PII jcb.200806088
PMID 19047463
PMC PMC2592831
MeSH Adaptor Protein Complex 2 / genetics Adaptor Protein Complex 2 / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans / ultrastructure Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Clathrin / metabolism* Endocytosis* Mutation Neuromuscular Junction / metabolism* Neuromuscular Junction / ultrastructure Recombinant Fusion Proteins / metabolism Synaptic Transmission* Synaptic Vesicles / metabolism*
IF 8.811
引用数 34
WOS 分野 CELL BIOLOGY
リソース情報
線虫 tm920