論文 - 詳細
| RRC ID | 42361 |
|---|---|
| 著者 | Zhang K, Simon CG Jr, Washburn NR, Antonucci JM, Lin-Gibson S. |
| タイトル | In situ formation of blends by photopolymerization of poly(ethylene glycol) dimethacrylate and polylactide. |
| ジャーナル | Biomacromolecules |
| Abstract |
Blends of cross-linked poly(ethylene glycol) dimethacrylate (PEGDMA) and poly(d,l-lactide) (PLA) were prepared by mixing photoactive PEGDMA (molecular mass: 875 g/mol) and PLA, and subsequently photopolymerizing the mixture with visible light. The effects of PLA molecular mass and mass fraction on the rheological properties of the PEGDMA/PLA mixtures, and on the degree of methacrylate vinyl conversion (DC), as well as blend miscibility, microstructure, mechanical properties, in vitro swelling behavior, and cell responses were studied. PLA-2K (molecular mass: 2096 g/mol) and PLA-63K (molecular mass: 63 000 g/mol) formed miscible and partially miscible blends with cross-linked PEGDMA, respectively. The addition of the PLA-2K did not affect the immediate or post-cure (>24 h) DC of the PEGDMA upon photopolymerization. However, the addition of PLA-63K decreased the immediate DC of the PEGDMA, which can be increased through extending the curing time or post-curing period. Compared to the cross-linked neat PEGDMA and PLA-2K/PEGDMA blends, PLA-63K/PEGDMA blends were significantly stronger, stiffer, and tougher. Both types of blends and the cross-linked PEGDMA swelled when soaked in a phosphate buffered saline (PBS) solution. The attachment and spreading of MCT3-E1 cells increased with increasing PLA-63K content in the blends. The facile and rapid formation of PEGDMA/PLA blends by photopolymerization represents a simple and efficient approach to a class of biomaterials with a broad spectrum of properties. |
| 巻・号 | 6(3) |
| ページ | 1615-22 |
| 公開日 | 2005-1-1 |
| DOI | 10.1021/bm0500648 |
| PMID | 15877385 |
| MeSH | Acrylates / chemical synthesis* Acrylates / pharmacology Animals Cells, Cultured Mice Photic Stimulation / methods* Polyesters / chemical synthesis* Polyesters / pharmacology Polyethylene Glycols / chemical synthesis* Polyethylene Glycols / pharmacology Polyethylene Glycols / radiation effects Polymers / chemical synthesis* Polymers / pharmacology Polymers / radiation effects Tensile Strength / drug effects Tensile Strength / radiation effects |
| IF | 6.092 |
| 引用数 | 18 |
| WOS 分野 | POLYMER SCIENCE CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |