論文 - 詳細
| RRC ID | 42386 |
|---|---|
| 著者 | Gregory P, Kraemer E, Zürcher G, Gentinetta R, Rohrbach V, Brodbeck U, Andres AC, Ziemiecki A, Bütikofer P. |
| タイトル | GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton. |
| ジャーナル | Bone |
| Abstract |
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and has a well-characterized biochemistry; however, its physiological role is completely unknown. Previous investigations into GPI-PLD have focused on the adult animal or on in vitro systems and a putative role in development has been neither proposed nor investigated. We describe the first evidence of GPI-PLD expression during mouse embryonic ossification. GPI-PLD expression was detected predominantly at sites of skeletal development, increasing during the course of gestation. GPI-PLD was observed during both intramembraneous and endochondral ossification and localized predominantly to the extracellular matrix of chondrocytes and to primary trabeculae of the skeleton. In addition, the mouse chondrocyte cell line ATDC5 expressed GPI-PLD after experimental induction of differentiation. These results implicate GPI-PLD in the process of bone formation during mouse embryogenesis. |
| 巻・号 | 37(2) |
| ページ | 139-47 |
| 公開日 | 2005-8-1 |
| DOI | 10.1016/j.bone.2005.04.015 |
| PII | S8756-3282(05)00146-8 |
| PMID | 15946906 |
| MeSH | Animals Bone and Bones / embryology Bone and Bones / metabolism* Cell Differentiation Cell Line Chondrocytes / cytology Chondrocytes / metabolism Extracellular Matrix / metabolism* Immunoblotting Immunohistochemistry Mice Phospholipase D / metabolism* Reverse Transcriptase Polymerase Chain Reaction |
| IF | 4.147 |
| 引用数 | 7 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |