論文 - 詳細
| RRC ID | 4241 |
|---|---|
| 著者 | Hukema RK, Rademakers S, Jansen G. |
| タイトル | Gustatory plasticity in C. elegans involves integration of negative cues and NaCl taste mediated by serotonin, dopamine, and glutamate. |
| ジャーナル | Learn Mem |
| Abstract |
While naïve Caenorhabditis elegans individuals are attracted to 0.1-200 mM NaCl, they become strongly repelled by these NaCl concentrations after prolonged exposure to 100 mM NaCl. We call this behavior gustatory plasticity. Here, we show that C. elegans displays avoidance of low NaCl concentrations only when pre-exposure to NaCl is combined with a negative stimulus, e.g., a repellent, or in the absence of food. By testing serotonin and/or dopamine signaling mutants and rescue by exogenously supplying these neurotransmitters, we found that serotonin and dopamine play a role during the plasticity response, while serotonin is also required during development. In addition, we also show that glutamate plays an important role in the response to NaCl, both in chemoattraction to NaCl and in gustatory plasticity. Thus, C. elegans can associate NaCl with negative stimuli using dopaminergic, serotonergic, and glutamatergic neurotransmission. Finally, we show that prolonged starvation enhances gustatory plasticity and can induce avoidance of NaCl in most gustatory plasticity mutants tested. Only mutation of the glutamate-gated Cl(-) channel gene avr-15 affected starvation-enhanced gustatory plasticity. These results suggest that starvation induces avoidance of NaCl largely independent of the normal gustatory plasticity mechanism. |
| 巻・号 | 15(11) |
| ページ | 829-36 |
| 公開日 | 2008-11-1 |
| DOI | 10.1101/lm.994408 |
| PII | 15/11/829 |
| PMID | 18984564 |
| MeSH | Animals Biogenic Monoamines / metabolism* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Chemotaxis / physiology* Cues* Dopamine / metabolism Dose-Response Relationship, Drug Food Deprivation Glutamic Acid / metabolism Neuronal Plasticity / drug effects Neuronal Plasticity / physiology* Neurons / drug effects Neurons / physiology Serotonin / metabolism Sodium Chloride / pharmacology* Taste / physiology* Taste Perception / drug effects* |
| IF | 2.359 |
| 引用数 | 43 |
| WOS 分野 | PSYCHOLOGY, EXPERIMENTAL NEUROSCIENCES |
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| 線虫 | tm351 tm903 tm669 |