論文 - 詳細
| RRC ID | 42506 |
|---|---|
| 著者 | Yamaguchi N, Argueta JG, Masuhiro Y, Kagishita M, Nonaka K, Saito T, Hanazawa S, Yamashita Y. |
| タイトル | Adiponectin inhibits Toll-like receptor family-induced signaling. |
| ジャーナル | FEBS Lett |
| Abstract |
Recent studies have shown that adiponectin, an adipocyte-derived cytokine, acts as a potent inhibitor of inflammatory responses. It has been also demonstrated that bacterial and viral signalings in host cells are triggered via Toll-like receptor (TLR) molecules. Therefore, in the present study, we investigated whether globular adiponectin (gAd) would be able to inhibit TLR-mediated nuclear factor-kappaB (NF-kappaB) signaling in mouse macrophages (RAW264). gAd predominantly bound to the AdipoR1 receptor and suppressed TLR-mediated NF-kappaB signaling. gAd-mediated inhibition of TLR-mediated IkappaB phosphorylation and NF-kappaB activation was eliminated by the pretreatment of cycloheximide. Also their inhibitions of gAd were blocked by preincubation of the cells with an antibody against AdipoR1, but not with an antibody against AdipoR2. Taken together, these findings indicate that adiponectin negatively regulates macrophage-like cell response to TLR ligands via an unknown endogenous product(s). |
| 巻・号 | 579(30) |
| ページ | 6821-6 |
| 公開日 | 2005-12-19 |
| DOI | 10.1016/j.febslet.2005.11.019 |
| PII | S0014-5793(05)01379-7 |
| PMID | 16325814 |
| MeSH | 3T3-L1 Cells Adipocytes / drug effects Adiponectin / analysis Adiponectin / genetics Adiponectin / metabolism Adiponectin / pharmacology Animals Biotinylation Cell Line Cycloheximide / pharmacology Dose-Response Relationship, Drug Genes, Reporter Glutathione Transferase / metabolism I-kappa B Kinase / metabolism Luciferases / metabolism Macrophages / drug effects Mice NF-kappa B / metabolism Phosphorylation / drug effects Protein Synthesis Inhibitors / pharmacology Receptors, Adiponectin Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism Recombinant Fusion Proteins / metabolism Signal Transduction / drug effects* Toll-Like Receptor 2 / antagonists & inhibitors* Toll-Like Receptor 2 / metabolism Toll-Like Receptor 4 / antagonists & inhibitors* Toll-Like Receptor 4 / metabolism Toll-Like Receptor 9 / antagonists & inhibitors* Toll-Like Receptor 9 / metabolism |
| IF | 3.057 |
| 引用数 | 182 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |