Reference - Detail
| RRC ID | 42511 |
|---|---|
| Author | Wakana K, Akiyama Y, Aso T, Yuasa Y. |
| Title | Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. |
| Journal | Cancer Lett |
| Abstract |
To clarify the role of GATA transcription factors in ovarian carcinogenesis, we analyzed the expression and methylation states of GATA-4/-5/-6 in eight human ovarian cancer cell lines. GATA-4/-5 were methylated in three and two cell lines without their expression, respectively. Methylation of GATA-4/-5 was also detected in nine and five of 15 primary ovarian cancers, respectively. GATA-6 was not methylated in any cases. We transiently over-expressed GATA-5 in the JHOC-5 cell line using an adenovirus system, resulting in that apoptosis was induced and apoptosis-related genes, such as Apaf-1, were up-regulated. These data suggest that GATA-4/-5 may be involved in ovarian carcinogenesis. |
| Volume | 241(2) |
| Pages | 281-8 |
| Published | 2006-9-28 |
| DOI | 10.1016/j.canlet.2005.10.039 |
| PII | S0304-3835(05)00958-4 |
| PMID | 16337738 |
| MeSH | Adenocarcinoma, Clear Cell / genetics Adenocarcinoma, Clear Cell / metabolism Apoptosis Carcinoma, Endometrioid / genetics Carcinoma, Endometrioid / metabolism Cell Proliferation Cystadenocarcinoma, Serous / genetics Cystadenocarcinoma, Serous / metabolism DNA Methylation* DNA, Neoplasm / genetics DNA, Neoplasm / metabolism Female GATA4 Transcription Factor / genetics* GATA5 Transcription Factor / genetics* GATA6 Transcription Factor / genetics* Gene Expression Regulation, Neoplastic / physiology* Gene Silencing Humans Ovarian Neoplasms / genetics* Ovarian Neoplasms / metabolism Promoter Regions, Genetic |
| IF | 7.36 |
| Times Cited | 36 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | OMC-3(RCB0755) JHOC-5(RCB1520) HTOA(RCB0692) JHOS-3(RCB1546) |