| RRC ID |
42536
|
| Author |
Mori M, Nakajima M, Mikami Y, Seki S, Takigawa M, Kubo T, Ikegawa S.
|
| Title |
Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Cartilage intermediate layer protein (CILP) is an extracellular matrix protein abundant in cartilaginous tissues. CILP is implicated in common musculoskeletal disorders, including osteoarthritis and lumbar disc disease. Regulation of the CILP gene is largely unknown, however. We have found that CILP mRNA expression is induced by TGF-beta1 and dependent upon signaling via TGF-beta receptors. TGF-beta1 induction of CILP is mediated by Smad3, which acts directly through cis-elements in the CILP promoter region. Pathways other than Smad3 also are involved in TGF-beta1 induction of CILP. These observations, together with the finding that CILP protein binds and inhibits TGF-beta1, suggest that CILP and TGF-beta1 may form a functional feedback loop that controls chondrocyte metabolism.
|
| Volume |
341(1)
|
| Pages |
121-7
|
| Published |
2006-3-3
|
| DOI |
10.1016/j.bbrc.2005.12.159
|
| PII |
S0006-291X(05)02940-2
|
| PMID |
16413503
|
| MeSH |
Cell Line
Chondrocytes / drug effects
Chondrocytes / metabolism*
Extracellular Matrix Proteins / metabolism*
Gene Expression Regulation / drug effects
Gene Expression Regulation / physiology
Humans
Pyrophosphatases / metabolism*
Receptors, Transforming Growth Factor beta / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology
Smad3 Protein / metabolism*
Transcriptional Activation / drug effects
Transcriptional Activation / physiology*
Transforming Growth Factor beta / metabolism*
Transforming Growth Factor beta1
|
| IF |
2.985
|
| Times Cited |
18
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
ATDC5(RCB0565)
HuH-7(RCB1366) |
