論文 - 詳細
| RRC ID | 42548 |
|---|---|
| 著者 | Tao RH, Kawate H, Ohnaka K, Ishizuka M, Hagiwara H, Takayanagi R. |
| タイトル | Opposite effects of alternative TZF spliced variants on androgen receptor. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR). In the present study, we further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR. Deletion analysis of TZF-L revealed that its N-terminus, which almost corresponded to that of TZF, but not its C-terminus was able to interact with AR. Additional analysis suggested that TZF and TZF-L were able to form both homodimers and heterodimers. TZF-L inhibited the homodimer formation of TZF and the intranuclear dot formation of TZF. We propose that in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively. |
| 巻・号 | 341(2) |
| ページ | 515-21 |
| 公開日 | 2006-3-10 |
| DOI | 10.1016/j.bbrc.2005.12.213 |
| PII | S0006-291X(06)00045-3 |
| PMID | 16446156 |
| MeSH | Alternative Splicing* Amino Acid Motifs Animals COS Cells Cell Line, Tumor Chlorocebus aethiops Dimerization Gene Deletion Genes, Reporter Humans Immunoblotting Immunoprecipitation Mice Microscopy, Confocal Models, Biological NIH 3T3 Cells Plasmids / metabolism Protein Isoforms Protein Structure, Tertiary Receptors, Androgen / metabolism* Repressor Proteins / chemistry Repressor Proteins / metabolism* Transcriptional Activation Transfection |
| IF | 2.985 |
| 引用数 | 10 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) |