RRC ID 42700
Author Osaki T, Takagi S, Hoshino Y, Okumura M, Fujinaga T.
Title Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models.
Journal Cancer Lett
Abstract Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3h or 15min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature.
Volume 248(1)
Pages 47-57
Published 2007-4-8
DOI 10.1016/j.canlet.2006.05.021
PII S0304-3835(06)00402-2
PMID 16837129
MeSH Animals Antineoplastic Agents / therapeutic use Blood Flow Velocity / drug effects Blotting, Western Cell Line, Tumor Female Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Laser-Doppler Flowmetry Mice Mice, Inbred C3H Mice, Inbred DBA Neoplasms, Experimental / blood supply Neoplasms, Experimental / drug therapy* Neoplasms, Experimental / pathology Neovascularization, Pathologic / drug therapy* Neovascularization, Pathologic / metabolism Neovascularization, Pathologic / pathology Photochemotherapy / methods* Porphyrins / therapeutic use* Time Factors Tumor Burden / drug effects Verteporfin
IF 6.508
Times Cited 12
Human and Animal Cells