論文 - 詳細
| RRC ID | 42701 |
|---|---|
| 著者 | Yamaguchi T, Saneyoshi M, Takahashi H, Hirokawa S, Amano R, Liu X, Inomata M, Maruyama T. |
| タイトル | Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin g (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells. |
| ジャーナル | Nucleosides Nucleotides Nucleic Acids |
| Abstract |
Telomerase, responsible for telomere synthesis, is expressed in approximately 90% of human tumor cells but seldom in normal somatic cells. In this study, inhibition by carbocyclic oxetanocin G triphosphate (C. OXT-GTP) and its analogues was investigated in order to clarify the susceptibility of telomerase to various nucleotide analogues. C. OXT-GTP competitively inhibited telomerase activity with respect to dGTP However, C. OXT-GTP had a potent inhibitory effect on DNA polymerase alpha. It was examined whether the nucleoside (C. OXT-G) was able to alter telomere length in cultured human HL60 cells. Contrary to expectation, long-term treatment with 10 microM C. OXT-G was found to cause telomere lengthening. |
| 巻・号 | 25(4-6) |
| ページ | 539-51 |
| 公開日 | 2006-1-1 |
| DOI | 10.1080/15257770600684217 |
| PMID | 16838844 |
| MeSH | Animals Guanine / analogs & derivatives* Guanine / chemistry Guanine / pharmacology Guanosine Triphosphate / chemistry* HL-60 Cells Humans Molecular Structure Salmon / metabolism Telomerase / antagonists & inhibitors* Telomere / drug effects* Telomere / genetics Telomere / metabolism |
| IF | 1.556 |
| 引用数 | 17 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) HeLa |