| RRC ID |
42701
|
| Author |
Yamaguchi T, Saneyoshi M, Takahashi H, Hirokawa S, Amano R, Liu X, Inomata M, Maruyama T.
|
| Title |
Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin g (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells.
|
| Journal |
Nucleosides Nucleotides Nucleic Acids
|
| Abstract |
Telomerase, responsible for telomere synthesis, is expressed in approximately 90% of human tumor cells but seldom in normal somatic cells. In this study, inhibition by carbocyclic oxetanocin G triphosphate (C. OXT-GTP) and its analogues was investigated in order to clarify the susceptibility of telomerase to various nucleotide analogues. C. OXT-GTP competitively inhibited telomerase activity with respect to dGTP However, C. OXT-GTP had a potent inhibitory effect on DNA polymerase alpha. It was examined whether the nucleoside (C. OXT-G) was able to alter telomere length in cultured human HL60 cells. Contrary to expectation, long-term treatment with 10 microM C. OXT-G was found to cause telomere lengthening.
|
| Volume |
25(4-6)
|
| Pages |
539-51
|
| Published |
2006-1-1
|
| DOI |
10.1080/15257770600684217
|
| PMID |
16838844
|
| MeSH |
Animals
Guanine / analogs & derivatives*
Guanine / chemistry
Guanine / pharmacology
Guanosine Triphosphate / chemistry*
HL-60 Cells
Humans
Molecular Structure
Salmon / metabolism
Telomerase / antagonists & inhibitors*
Telomere / drug effects*
Telomere / genetics
Telomere / metabolism
|
| IF |
1.556
|
| Times Cited |
17
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
