RRC ID |
42701
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著者 |
Yamaguchi T, Saneyoshi M, Takahashi H, Hirokawa S, Amano R, Liu X, Inomata M, Maruyama T.
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タイトル |
Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin g (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells.
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ジャーナル |
Nucleosides Nucleotides Nucleic Acids
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Abstract |
Telomerase, responsible for telomere synthesis, is expressed in approximately 90% of human tumor cells but seldom in normal somatic cells. In this study, inhibition by carbocyclic oxetanocin G triphosphate (C. OXT-GTP) and its analogues was investigated in order to clarify the susceptibility of telomerase to various nucleotide analogues. C. OXT-GTP competitively inhibited telomerase activity with respect to dGTP However, C. OXT-GTP had a potent inhibitory effect on DNA polymerase alpha. It was examined whether the nucleoside (C. OXT-G) was able to alter telomere length in cultured human HL60 cells. Contrary to expectation, long-term treatment with 10 microM C. OXT-G was found to cause telomere lengthening.
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巻・号 |
25(4-6)
|
ページ |
539-51
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公開日 |
2006-1-1
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DOI |
10.1080/15257770600684217
|
PMID |
16838844
|
MeSH |
Animals
Guanine / analogs & derivatives*
Guanine / chemistry
Guanine / pharmacology
Guanosine Triphosphate / chemistry*
HL-60 Cells
Humans
Molecular Structure
Salmon / metabolism
Telomerase / antagonists & inhibitors*
Telomere / drug effects*
Telomere / genetics
Telomere / metabolism
|
IF |
1.556
|
引用数 |
17
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WOS 分野
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BIOCHEMISTRY & MOLECULAR BIOLOGY
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リソース情報 |
ヒト・動物細胞 |
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