論文 - 詳細
| RRC ID | 42707 |
|---|---|
| 著者 | Suzuki T, Tazoe H, Taguchi K, Koyama Y, Ichikawa H, Hayakawa S, Munakata H, Isemura M. |
| タイトル | DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. |
| ジャーナル | Biomed Res |
| Abstract |
Using a DNA microarray, we analyzed about 16,600 genes for changes in expression associated with the differentiation of human promyelocytic leukemia HL-60 cells induced by 1alpha,25-dihydroxyvitamin D3 (DVD). Many of the up-regulated genes could be correlated to differentiation-associated changes toward a monocyte/macrophage lineage, and many down-regulated genes could be correlated to repressed cell growth. The present study revealed the down-regulated gene expression of importins and exportins 1, 5, 7, and exportin-tRNA. Thus, the present results confirmed our previous findings of down-regulation of exportin 1 and exportin-tRNA by DVD. Gene expression of exportin 6 is suggested to be regulated differently from that of exportins 1, 5, 7, and exportin-tRNA. The down-regulation of nuclear transport factors may be deeply associated with the differentiation of HL-60 cells induced by DVD. |
| 巻・号 | 27(3) |
| ページ | 99-109 |
| 公開日 | 2006-6-1 |
| DOI | 10.2220/biomedres.27.99 |
| PII | JST.JSTAGE/biomedres/27.99 |
| PMID | 16847355 |
| MeSH | Calcitriol / pharmacology* Cell Proliferation DNA Primers / chemistry Gene Expression Regulation, Neoplastic* HL-60 Cells Humans Karyopherins / biosynthesis Karyopherins / metabolism Leukemia, Promyelocytic, Acute / metabolism* Macrophages / metabolism Monocytes / metabolism Oligonucleotide Array Sequence Analysis / methods* Reverse Transcriptase Polymerase Chain Reaction |
| IF | 1.429 |
| 引用数 | 21 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |