Reference - Detail
| RRC ID | 42745 |
|---|---|
| Author | Arung ET, Shimizu K, Kondo R. |
| Title | Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis. |
| Journal | Biol Pharm Bull |
| Abstract |
In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin. |
| Volume | 29(9) |
| Pages | 1966-9 |
| Published | 2006-9-1 |
| DOI | 10.1248/bpb.29.1966 |
| PII | JST.JSTAGE/bpb/29.1966 |
| PMID | 16946519 |
| MeSH | Agaricales / enzymology Animals Antioxidants / pharmacology Artocarpus / chemistry* Cell Line, Tumor Enzyme Inhibitors / pharmacology* Flavones / pharmacology* Melanins / biosynthesis* Melanoma, Experimental / metabolism Mice Monophenol Monooxygenase / antagonists & inhibitors* Plant Extracts / pharmacology |
| IF | 1.863 |
| Times Cited | 55 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | B16 |