RRC ID 42746
著者 Akazawa H, Akihisa T, Taguchi Y, Banno N, Yoneima R, Yasukawa K.
タイトル Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense.
ジャーナル Biol Pharm Bull
Abstract Melanogenesis inhibitory and free radical scavenging activities of nine cyclic (1-9) and one acyclic diarylheptanoids (10), and two phenolic compounds, (+)-rhododendrol (11) and (+)-catechin (12), isolated from the ethyl acetate-soluble fraction of the MeOH extract of the bark of Acer nikoense MAXIM. (Aceraceae) were examined. Upon evaluation of compounds 1-12 on the melanogenesis in the B16 melanoma cells, two compounds, 2 and 8, exhibited marked inhibitory activity with 55.6% and 46.8% reduction, respectively, of melanin content at 25 microg/ml without inhibition of cell proliferation. In addition, upon an evaluation of eleven compounds, 1-7 and 9-12 against the scavenging activities of free radicals (against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical), compound 12 (IC(50) 9.0 microgM) followed by compounds 1, 3, 4, and 6 (IC(50) 40.2-44.0 microgM) showed potent scavenging activities.
巻・号 29(9)
ページ 1970-2
公開日 2006-9-1
DOI 10.1248/bpb.29.1970
PII JST.JSTAGE/bpb/29.1970
PMID 16946520
MeSH Acer / chemistry* Animals Diarylheptanoids / pharmacology* Free Radical Scavengers / pharmacology* Melanins / biosynthesis* Mice Phenols / pharmacology* Plant Bark / chemistry* Plant Extracts / pharmacology*
IF 1.863
引用数 53
WOS 分野 PHARMACOLOGY & PHARMACY
リソース情報
ヒト・動物細胞 B16