論文 - 詳細
| RRC ID | 42774 |
|---|---|
| 著者 | Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H. |
| タイトル | Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. |
| ジャーナル | J Immunol |
| Abstract |
Recent lines of evidence have demonstrated that IL-27, a newly identified IL-12-related cytokine, has two apparently conflicting roles in immune responses: one as an initiator of Th1 responses and the other as an attenuator of inflammatory cytokine production. Although the IL-27-mediated Th1 initiation mechanism has been elucidated, little is known about the molecular basis for the suppression of cytokine production. In the present study, we demonstrated that IL-27 suppressed the production of various proinflammatory cytokines by fully activated CD4+ T cells while it had no effect on the cytokine production by CD4+ T cells at early phases of activation. IL-27 also suppressed IL-17 production by activated CD4+ T cells, thereby counteracting IL-23, another IL-12-related cytokine with proinflammatory effects. In fully activated CD4+ T cells, STAT3 was preferentially activated by IL-27 stimulation, whereas both STAT1 and 3 were activated by IL-27 in early activated CD4+ T cells. Lack of STAT3 in fully activated cells impaired the suppressive effects of IL-27. These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1. |
| 巻・号 | 177(8) |
| ページ | 5377-85 |
| 公開日 | 2006-10-15 |
| DOI | 10.4049/jimmunol.177.8.5377 |
| PII | 177/8/5377 |
| PMID | 17015723 |
| MeSH | Animals CD4-Positive T-Lymphocytes / immunology* Cell Differentiation / immunology* Cell Line Cytokines / biosynthesis Humans Interleukin-17 / biosynthesis* Interleukin-23 / physiology* Interleukins / physiology* Lymphocyte Activation Mice Mice, Knockout Receptors, Cytokine / physiology Receptors, Interleukin STAT3 Transcription Factor / metabolism STAT3 Transcription Factor / physiology* Th1 Cells / cytology* |
| IF | 4.886 |
| 引用数 | 179 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |