| RRC ID |
42774
|
| 著者 |
Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H.
|
| タイトル |
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.
|
| ジャーナル |
J Immunol
|
| Abstract |
Recent lines of evidence have demonstrated that IL-27, a newly identified IL-12-related cytokine, has two apparently conflicting roles in immune responses: one as an initiator of Th1 responses and the other as an attenuator of inflammatory cytokine production. Although the IL-27-mediated Th1 initiation mechanism has been elucidated, little is known about the molecular basis for the suppression of cytokine production. In the present study, we demonstrated that IL-27 suppressed the production of various proinflammatory cytokines by fully activated CD4+ T cells while it had no effect on the cytokine production by CD4+ T cells at early phases of activation. IL-27 also suppressed IL-17 production by activated CD4+ T cells, thereby counteracting IL-23, another IL-12-related cytokine with proinflammatory effects. In fully activated CD4+ T cells, STAT3 was preferentially activated by IL-27 stimulation, whereas both STAT1 and 3 were activated by IL-27 in early activated CD4+ T cells. Lack of STAT3 in fully activated cells impaired the suppressive effects of IL-27. These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1.
|
| 巻・号 |
177(8)
|
| ページ |
5377-85
|
| 公開日 |
2006-10-15
|
| DOI |
10.4049/jimmunol.177.8.5377
|
| PII |
177/8/5377
|
| PMID |
17015723
|
| MeSH |
Animals
CD4-Positive T-Lymphocytes / immunology*
Cell Differentiation / immunology*
Cell Line
Cytokines / biosynthesis
Humans
Interleukin-17 / biosynthesis*
Interleukin-23 / physiology*
Interleukins / physiology*
Lymphocyte Activation
Mice
Mice, Knockout
Receptors, Cytokine / physiology
Receptors, Interleukin
STAT3 Transcription Factor / metabolism
STAT3 Transcription Factor / physiology*
Th1 Cells / cytology*
|
| IF |
4.886
|
| 引用数 |
179
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
