論文 - 詳細
| RRC ID | 42777 |
|---|---|
| 著者 | Shao RX, Kato N, Lin LJ, Muroyama R, Moriyama M, Ikenoue T, Watabe H, Otsuka M, Guleng B, Ohta M, Tanaka Y, Kondo S, Dharel N, Chang JH, Yoshida H, Kawabe T, Omata M. |
| タイトル | Absence of tyrosine kinase mutations in Japanese colorectal cancer patients. |
| ジャーナル | Oncogene |
| Abstract |
Tyrosine kinases, which are important regulators of intracellular signal-transduction pathways, have mutated forms that are often associated with oncogenesis and are attractive targets for therapeutic intervention. Recently, systematic mutational analyses of tyrosine kinases revealed that a minimum of 30% of colorectal cancer contain at least one mutation in the tyrosine kinases. To further explore these mutations, we examined all reported mutations of NTRK3, FES, KDR, EPHA3, NTRK2, JAK1, PDGFRA, EPHA7, EPHA8, ERBB4, FGFR1, MLK4 and GUCY2F genes in the 24 colorectal cancer cell lines. Unexpectedly, among 24 colorectal cancer cell lines, only two cell lines (LoVo and CaR1) harbored mutation C1408T (R470C) in MLK4 gene. The mutation rate was extremely low compared to that previously reported. Therefore, we analyzed mutations in 46 colorectal cancer samples resected from the same number of Japanese patients. Surprisingly, none of the 46 samples contained any of the mutations reported. Based on our study, we advise that a more comprehensive tyrosine kinase gene mutation assay is necessary in the future. |
| 巻・号 | 26(14) |
| ページ | 2133-5 |
| 公開日 | 2007-3-29 |
| DOI | 10.1038/sj.onc.1210007 |
| PII | 1210007 |
| PMID | 17016444 |
| MeSH | Aged Asian People / genetics Cell Line, Tumor Colorectal Neoplasms / enzymology Colorectal Neoplasms / genetics* DNA Mutational Analysis Female Humans Male Middle Aged Mutation Protein-Tyrosine Kinases / genetics* |
| IF | 7.971 |
| 引用数 | 11 |
| WOS 分野 | GENETICS & HEREDITY ONCOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) LoVo(RCB1639) COLO-320(RCB1193) COLO205(RCB2127) |