RRC ID 42881
Author Sakuma M, Akahira J, Ito K, Niikura H, Moriya T, Okamura K, Sasano H, Yaegashi N.
Title Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer.
Journal Cancer Sci.
Abstract 2 cm) (P = 0.027 and P = 0.031, respectively). Based on univariate analysis, patients with aberrant methylation of the Cyclin D2 promoter had a significantly worse chance of disease-free survival than those without methylation (P = 0.021). Our results suggest that aberrant promoter methylation of the Cyclin D2 gene is significantly associated with patient prognosis in epithelial ovarian cancer.
Volume 98(3)
Pages 380-6
Published 2007-3
DOI 10.1111/j.1349-7006.2007.00394.x
PMID 17270028
MeSH Antimetabolites, Antineoplastic / pharmacology Azacitidine / analogs & derivatives Azacitidine / pharmacology Cell Line, Tumor Cyclin D2 Cyclins / genetics* Cyclins / metabolism DNA Methylation* Decitabine Enzyme Inhibitors / pharmacology Female Humans Hydroxamic Acids / pharmacology Immunohistochemistry Ovarian Neoplasms / diagnosis* Ovarian Neoplasms / genetics Ovarian Neoplasms / metabolism* Ovarian Neoplasms / pathology Prognosis Promoter Regions, Genetic* RNA, Messenger / analysis Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction
IF 4.372
Times Cited 13
Human and Animal Cells