RRC ID 42883
Author Komatsu W, Mawatari K, Miura Y, Yagasaki K.
Title Restoration by dietary glutamine of reduced tumor necrosis factor production in a low-protein-diet-fed rat model.
Journal Biosci. Biotechnol. Biochem.
Abstract Tumor necrosis factor-alpha (TNF) production by peritoneal macrophages and its dietary modification were investigated by using rats fed on a low-protein diet. The rats were given a 20% casein (control) diet or a 3% casein diet for 21 days, and TNF production was measured in activated macrophages of these animals. TNF production was significantly lower in macrophages from rats fed on the low-protein diet than that in macrophages from rats fed on the control diet. Oral administration of a cabbage extract, a known modulator of TNF production, to the low-protein-diet-fed rats significantly enhanced TNF production by macrophages. Glutamine supplementation to the low-protein diet significantly enhanced TNF production as well as TNF mRNA expression. These results indicate that the 3%-casein-diet-fed rat would be useful as a model for reduced TNF production in protein malnutrition. These results also suggest that glutamine administration restored the reduced TNF production associated with protein malnutrition.
Volume 71(2)
Pages 352-7
Published 2007-2
DOI 10.1271/bbb.60271
PII JST.JSTAGE/bbb/60271
PMID 17284860
MeSH Amino Acids / blood Animals Blood Proteins / metabolism Brassica / chemistry Cells, Cultured Diet* Fibroblasts / metabolism Glutamine / pharmacology* Lipids / blood Macrophages, Peritoneal / drug effects Macrophages, Peritoneal / metabolism Mice Organ Size / drug effects Plant Extracts / pharmacology Protein Deficiency / metabolism* Rats Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factors / biosynthesis*
IF 1.297
Times Cited 5
WOS Category CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells