| RRC ID |
42883
|
| Author |
Komatsu W, Mawatari K, Miura Y, Yagasaki K.
|
| Title |
Restoration by dietary glutamine of reduced tumor necrosis factor production in a low-protein-diet-fed rat model.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Tumor necrosis factor-alpha (TNF) production by peritoneal macrophages and its dietary modification were investigated by using rats fed on a low-protein diet. The rats were given a 20% casein (control) diet or a 3% casein diet for 21 days, and TNF production was measured in activated macrophages of these animals. TNF production was significantly lower in macrophages from rats fed on the low-protein diet than that in macrophages from rats fed on the control diet. Oral administration of a cabbage extract, a known modulator of TNF production, to the low-protein-diet-fed rats significantly enhanced TNF production by macrophages. Glutamine supplementation to the low-protein diet significantly enhanced TNF production as well as TNF mRNA expression. These results indicate that the 3%-casein-diet-fed rat would be useful as a model for reduced TNF production in protein malnutrition. These results also suggest that glutamine administration restored the reduced TNF production associated with protein malnutrition.
|
| Volume |
71(2)
|
| Pages |
352-7
|
| Published |
2007-2-1
|
| DOI |
10.1271/bbb.60271
|
| PII |
JST.JSTAGE/bbb/60271
|
| PMID |
17284860
|
| MeSH |
Amino Acids / blood
Animals
Blood Proteins / metabolism
Brassica / chemistry
Cells, Cultured
Diet*
Fibroblasts / metabolism
Glutamine / pharmacology*
Lipids / blood
Macrophages, Peritoneal / drug effects
Macrophages, Peritoneal / metabolism
Mice
Organ Size / drug effects
Plant Extracts / pharmacology
Protein Deficiency / metabolism*
Rats
Reverse Transcriptase Polymerase Chain Reaction
Tumor Necrosis Factors / biosynthesis*
|
| IF |
1.516
|
| Times Cited |
5
|
|
WOS Category
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
L929 |
