論文 - 詳細
| RRC ID | 42888 |
|---|---|
| 著者 | Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT. |
| タイトル | Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), have been widely used in agriculture and industry. Although these compounds are known to have many toxic effects, including endocrine-disrupting effects, their effects on bone resorption are unknown. In this study, we investigated the effects of organotin compounds, such as monobutyltin (MBT), dibutyltin (DBT), TBT, and TPT, on osteoclast differentiation using mouse monocytic RAW264.7 cells. MBT and DBT had no effects, whereas TBT and TPT dose-dependently inhibited osteoclast differentiation at concentrations of 3-30 nM. Treatment with a retinoic acid receptor (RAR)-specific antagonist, Ro41-5253, restored the inhibition of osteoclastogenesis by TBT and TPT. TBT and TPT reduced receptor activator of nuclear factor-kappaB ligand (RANKL) induced nuclear factor of activated T cells (NFAT) c1 expression, and the reduction in NFATc1 expression was recovered by Ro41-5253. Our results suggest that TBT and TPT suppress osteoclastogenesis by inhibiting RANKL-induced NFATc1 expression via an RAR-dependent signaling pathway. |
| 巻・号 | 355(1) |
| ページ | 10-5 |
| 公開日 | 2007-3-30 |
| DOI | 10.1016/j.bbrc.2006.12.237 |
| PII | S0006-291X(06)02828-2 |
| PMID | 17291456 |
| MeSH | Animals Bone Resorption / physiopathology Cell Differentiation / drug effects* Cell Line Cell Survival / drug effects Macrophages Mice Organotin Compounds / pharmacology* Osteoclasts / cytology* Osteoclasts / drug effects Receptors, Retinoic Acid / antagonists & inhibitors Receptors, Retinoic Acid / physiology* Retinoid X Receptors / drug effects Retinoid X Receptors / physiology* Signal Transduction / drug effects Signal Transduction / physiology Trialkyltin Compounds / pharmacology* |
| IF | 2.985 |
| 引用数 | 22 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Policy sources |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |