論文 - 詳細
| RRC ID | 42907 |
|---|---|
| 著者 | Notoya M, Arai R, Katafuchi T, Minamino N, Hagiwara H. |
| タイトル | A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts. |
| ジャーナル | Eur J Pharmacol |
| Abstract |
We isolated a novel peptide, calcitonin receptor-stimulating peptide-1 (CRSP-1), from porcine brain and found that the administration of this peptide into rats induced a transient decrease in plasma calcium concentration. Therefore, we investigated the effects of CRSP-1 on osteoclastogenesis. Osteoclast-like cells were formed from spleen cells or bone marrow cells by a combination of the receptor activator of nuclear factor-kappaB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). CRSP-1 dose-dependently inhibited the formation of multinucleated osteoclast-like cells, and a calcitonin receptor inhibitor antagonized in part the inhibition of osteoclast formation by CRSP-1. Furthermore, CRSP-1 destroyed the actin ring that is a typical index of osteoclast resorption activity; it contributed to this action via the signaling pathway of protein kinase A. Our findings indicate that CRSP-1 inhibits osteoclastogenesis by inhibiting the formation and activity of multinucleated osteoclasts. The inhibitory effects of CRSP-1 on osteoclast metabolism were similar in degree to those of porcine calcitonin. CRSP-1 might provide a clue to the development of tools useful in the prevention and treatment of osteoporosis. |
| 巻・号 | 560(2-3) |
| ページ | 234-9 |
| 公開日 | 2007-4-10 |
| DOI | 10.1016/j.ejphar.2007.01.034 |
| PII | S0014-2999(07)00080-5 |
| PMID | 17328890 |
| MeSH | Actins / drug effects Animals Calcitonin Gene-Related Peptide / pharmacology* Cyclic AMP / biosynthesis Male Mice Osteoclasts / drug effects* Osteoclasts / physiology Osteoporosis / drug therapy Receptors, Calcitonin / biosynthesis* |
| IF | 3.263 |
| 引用数 | 20 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |